Journal
MICROBIOLOGY AND IMMUNOLOGY
Volume 55, Issue 2, Pages 130-134Publisher
WILEY
DOI: 10.1111/j.1348-0421.2010.00301.x
Keywords
cerebral infarction; hypoxia; IL-17A; PBMC; Th17
Categories
Funding
- National Natural Science Foundation of China [30570619]
Ask authors/readers for more resources
Studies have shown the IL-17A involvement in human ischemic stroke patients in vivo. Whether the IL-17A expression was originated from Th17 and could be stimulated by hypoxia remained unknown. Here we report the Th17 upregulation in anaerobic cultured PBMC from chronic stage patients of severe cerebral infarction. By using ELISA and FACS we examined IL-1 beta, IFN-gamma, IL-23 and IL-17A protein levels in the supernatants and Th1/Th17 ratios in PBMC. Statistical significance of Th17 but not Th1 upregulation was proved in 6-hr anaerobic cultured patient groups (P < 0.001). Hence, Th17 might be essential in the autoimmune pathogenesis when hypoxia recurs in severe ischemic stroke patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available