Journal
MICROBIOLOGY AND IMMUNOLOGY
Volume 54, Issue 3, Pages 170-174Publisher
WILEY
DOI: 10.1111/j.1348-0421.2010.00199.x
Keywords
lysosome; macrophage; Mycobacterium tuberculosis; phagosome
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Funding
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Ministry of Health, Labor and Welfare of Japan
- United States-Japan Cooperative Medical Science Committee
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M.tb is an intracellular pathogen which survives within the phagosomes of host macrophages by inhibiting their fusion with lysosomes. Here, it has been demonstrated that a lysosomal glycoprotein, CD63, is recruited to the majority of M.tb phagosomes, while RILP shows limited localization. This is consistent with the author's findings that CD63, but not RILP, is recruited to the phagosomes in macrophages expressing the dominant negative form of Rab7. These results suggest that M.tb phagosomes selectively fuse with endosomes and lysosomes to escape killing activity while acquiring nutrients.
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