Journal
MICROBIAL PATHOGENESIS
Volume 63, Issue -, Pages 19-23Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2013.05.014
Keywords
Nontyphoidal Salmonella; NTS; O-antigen; Conjugate vaccine
Categories
Funding
- GlaxoSmithKline
- Medical Research Council, UK
- MRC [G9818340] Funding Source: UKRI
- Medical Research Council [G9818340] Funding Source: researchfish
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Nontyphoidal Salmonella are a major and emerging cause of fatal invasive disease in Africa, and are genetically distinct from those found elsewhere in the world. Understanding the targets of protective immunity to these African Salmonellae is key to vaccine development. We immunized mice and rabbits with heat-inactivated wild-type African invasive Salmonella Typhimurium D23580 and rough mutants lacking O-antigen. Wild-type Salmonella, unlike rough bacteria, induced a large bactericidal antibody response mainly against O-antigen. Bactericidal ability of anti-O-antigen antibodies was confirmed following purification by affinity chromatography. The current findings support the development of an O-antigen conjugate vaccine against invasive nontyphoidal Salmonellae for Africa. (C) 2013 Elsevier Ltd. All rights reserved.
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