Journal
MICROBIAL PATHOGENESIS
Volume 52, Issue 6, Pages 367-374Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2012.03.007
Keywords
Salmonella; B cells; Macropinocytosis; SPI-1; Pyroptosis
Categories
Funding
- CONACYT [48687-M, 205934]
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We have previously reported that Salmonella infects B cells and survives within endosomal-lysosomal compartments. However, the mechanisms used by Salmonella to enter B cells remain unknown. In this study, we have shown that Salmonella induces its own entry by the induction of localized ruffling, macropinocytosis, and spacious phagosome formation. These events were associated with the rearrangement of actin and microtubule networks. The Salmonella pathogenesis island 1 (SPI-1) was necessary to invade B cells. In contrast to macrophages, B cells were highly resistant to cell death induced by Salmonella. These data demonstrate the ability of Salmonella to infect these non-professional phagocytic cells, where the bacterium can find an ideal intracellular niche to support persistence and the possible dissemination of infection. (c) 2012 Elsevier Ltd. All rights reserved.
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