Journal
MICROBIAL PATHOGENESIS
Volume 45, Issue 3, Pages 231-235Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2008.05.003
Keywords
Streptococcus agalactiae; Placenta; Trophoblast; Toll like receptors; Apoptosis; Cell death; Preterm delivery; GBS; beta-hemolysin; Invasion; Pregnancy
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Funding
- NIH NCRR GCRC [M01-RR00425]
- March of Dimes [6-FY06-329]
- Burroughs Wellcome Career Award in Biomedical Sciences
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Group B streptococcus (GBS) is one of the leading causes of neonatal infection: however the molecular mechanisms involved are not clearly known. Here we used high and low hemolytic GBS isolates and mutant GBS that lacks beta-hemolysin expression and showed that GBS infection or exposure to GBS hemolysin extract induces primary human trophoblast, placental fibroblast and JEG3 trophoblast cell line death, and that GBS-induced trophoblast death was beta-hemolysin dependent. The fibroblasts and trophoblasts provide an innate immune barrier between fetal and maternal circulation in the placenta. These data suggest that GBS may disrupt this barrier to invade fetal circulation. (C) 2008 Elsevier Ltd. All rights reserved.
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