Journal
MICROBIAL DRUG RESISTANCE
Volume 25, Issue 1, Pages 1-7Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/mdr.2018.0104
Keywords
Pseudomonas putida; multidrug resistance; whole genome; qnrVC6; bioinformatics
Funding
- National Key Research and Development Program of China [2016YFD04012021]
- Guangdong Special Support Program [2016TQ03 N682]
- Pearl River SAMP
- T Nova Program of Guangzhou [201710010061]
- National Natural Science Foundation of China [81201341]
- Science and Technology Planning Project of Guangdong Province [2017A050501007]
- National Outstanding Doctoral Dissertation Funding [201459]
- Fundamental Research Funds for the Central Universities [2017ZD092]
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This study aimed at identification and characterization of a novel multidrug-resistant Pseudomonas putida strain Guangzhou-Ppu420 carrying two copies of qnrVC6 isolated from a hospital in Guangzhou, China, in 2012. Antimicrobial susceptibility was tested by Vitek2 Automated Susceptibility System and Etest strips, and whole-genome sequencing facilitated analysis of its multidrug resistance. The genome has a length of 6,031,212bp and an average G+C content of 62.01%. A total of 5,421 open reading frames were identified, including eight 5S rRNA, seven 16S rRNA, and seven 23S rRNA, and 76 tRNA genes. Importantly, two copies of qnrVC6 gene with three ISCR1 around, a bla(VIM-2) carrying integron In528, a novel gcu173 carrying integron In1348, and six antibiotic resistance genes were identified. This is the first identification of two copies of the qnrVC6 gene in a single P. putida isolate and a class 1 integron In1348.
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