Journal
MICROBIAL CELL FACTORIES
Volume 9, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/1475-2859-9-3
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Funding
- U.S. National Science Foundation [EEC-0813570, CBET-0645188, BES-0331388/BES-0601549]
- U.S. Department of Agriculture Cooperative State Research, Education and Extension Service [2005-35504-16698]
- Directorate For Engineering
- Div Of Engineering Education and Centers [813570] Funding Source: National Science Foundation
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Volatility of oil prices along with major concerns about climate change, oil supply security and depleting reserves have sparked renewed interest in the production of fuels from renewable resources. Recent advances in synthetic biology provide new tools for metabolic engineers to direct their strategies and construct optimal biocatalysts for the sustainable production of biofuels. Metabolic engineering and synthetic biology efforts entailing the engineering of native and de novo pathways for conversion of biomass constituents to short-chain alcohols and advanced biofuels are herewith reviewed. In the foreseeable future, formal integration of functional genomics and systems biology with synthetic biology and metabolic engineering will undoubtedly support the discovery, characterization, and engineering of new metabolic routes and more efficient microbial systems for the production of biofuels.
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