Journal
MICROBES AND INFECTION
Volume 16, Issue 5, Pages 445-449Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2014.02.004
Keywords
Chronic hepatitis C; Genetic predisposition to disease; Single nucleotide polymorphism
Categories
Funding
- Russian Foundation for Basic Research [11-04-01206a, 14-04-00641a]
- Russian State Program for the Support of Leading Scientific Schools [NSh-4713.2014.4]
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Chronic hepatitis C is a severe liver disease caused by positive-strand RNA virus. Previously, we reported an association between seven single nucleotide polymorphisms (SNPs) in four innate immunity genes (OAS2, OAS3, CD209, and TLR3) and human predisposition to tick-borne encephalitis, caused by a virus from the same Flaviviridae family, in a Russian population. Currently, genotype and allele frequencies for these SNPs were analyzed in 75 chronic hepatitis C patients and compared with the population control (269 Novosibirsk citizens). Data obtained suggest that the OAS2 rs1293762 and CD209 rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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