Journal
MICROBES AND INFECTION
Volume 16, Issue 10, Pages 871-876Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2014.08.007
Keywords
Innate immune response; Immune signaling; Oxidative stress; ER stress; Heat shock
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Funding
- National Natural Science Foundation of China [81170056, 81100046]
- Key Medical grant from Shanghai Science and Technology Committee [11411951102, 12JC1402300]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
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Innate immunity as the first line of the immune system, provides initial protection against various pathogens and infections. Recent studies suggest a link between cell stress response and immune response upon exogenous insults in the lung. The key proteins in cellular stress responses were demonstrated to be involved in the activation and regulation of the immune signaling pathways. Further research on the function of these stress proteins in innate immunity defenses, particularly in pulmonary diseases and inflammation may help to clarify the disease pathogenesis and provide potential therapeutic treatments for various infectious and inflammatory lung diseases. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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