Journal
MICROBES AND INFECTION
Volume 16, Issue 9, Pages 762-767Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2014.07.009
Keywords
Human lactoferrin; Prophylaxis; Streptococcus mutans; Bacteremia
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Funding
- NIH NIDCR [R21 DE019548]
- New Jersey Health Foundation [PC123-13]
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Streptococcus mutans is the primary agent of dental caries, which is often detected in transient bacteremia. Lactoferrin is a multifunctional glycoprotein showing antibacterial activities against several Streptococcus species. We reported here the prophylactic effect of human lactoferrin (hLF) in a lactoferrin knockout mouse (LFKO-/-) bacteremic model. The hLF treatment significantly cleared S. mutans from the blood and organs of bacteremic mice when compared to the non-hLF treated mice. Further, analysis of serum cytokines, spleen and liver cytokine mRNA levels revealed that hLF prophylaxis modulates their release differently when compared to the non-hLF treated group. C-reactive protein level (P = 0.003) also decreased following hLF prophylaxis in S. mutans induced bacteremic mice. Additional quantitative RT-PCR analysis revealed that hLF prophylaxis significantly decreased the expression level of TN-gamma, TNF-alpha, IL-1 beta, IL-6, MPO and iNOS in spleen and liver. These results suggested that the hLF protects the host against S. mutans-induced experimental bacteremia. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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