Journal
MICROBES AND INFECTION
Volume 15, Issue 14-15, Pages 1005-1016Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2013.09.011
Keywords
Ehrlichia; Human monocytotropic ehrlichiosis; Zoonosis; Effector; Nucleomodulin; Tandem repeat protein; Moonlighting protein; Type 1 secretion system; Post translational modification
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Funding
- National Institute of Allergy and Infectious Diseases (NIAID) [AI105536]
- Clayton Foundation for Research
- NIH Emerging Infectious Diseases and Biodefense Training grant [T32 AI007536]
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Ehrlichia chaffeensis is an obligately intracellular gram negative bacterium with a small genome that thrives in mammalian mononuclear phagocytes by exploiting eukaryotic processes. Herein, we discuss the latest findings on moonlighting tandem repeat protein effectors and their secretion mechanisms, and novel molecular interkingdom interactions that provide insight into the intracellular pathobiology of ehrlichiae. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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