Journal
MICROBES AND INFECTION
Volume 15, Issue 10-11, Pages 669-676Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2013.05.003
Keywords
Platelets; Streptococcus; Sepsis
Categories
Funding
- Swedish Research Council [21112, 21587]
- Swedish Government Funds for Clinical Research (ALF)
- foundation of Crafoord
- foundation of Ake-Wiberg
- foundation of Harald Greta Jeansson
- foundation of Osterlund
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Platelets have been reported to contribute to inflammation and inflammatory disorders. In the present study, we demonstrate that platelets contribute to the acute response to bacterial infection in a mouse model of invasive Streptococcus pyogenes infection. Thrombocytopenia occurred rapidly in infected animals and this was associated with platelet activation, formation of platelet-neutrophil complexes and neutrophil activation. In order to assess the role of platelets during infection, platelets were depleted prior to infection. Platelet-depleted animals had significantly decreased platelet-neutrophil complex formation and neutrophil activation in response to infection. Importantly, significantly fewer bacteria disseminated to the blood, lungs, and spleen of platelet-depleted animals. Platelet-depleted animals did not decrease as significantly in weight as the infected control animals. The results demonstrate a previously unappreciated role for platelets during the pathophysiological response to infection, whereby S. pyogenes bacteria bind to platelets and platelets facilitate bacterial dissemination. (c) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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