Journal
MICROBES AND INFECTION
Volume 15, Issue 10-11, Pages 749-754Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2013.05.004
Keywords
Staphylococcus aureus; Interferon-gamma (IFN gamma); Polymorphonuclear leukocyte; Neutrophil; saeRIS; Peritonitis
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Funding
- National Institutes of Health [5R01AI090046-02]
- National Center for Research Resources [P20RR020185, P20RR16455-07]
- Montana State University Agriculture Experiment Station
- Murdoch Charitable Trust
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Invasive Staphylococcus aureus (S. aureus) disease is associated with neutrophil activity and pro-inflammatory cytokine expression, including interferon-gamma (IFN gamma). Using a mouse model of S. aureus peritonitis, we identify neutrophils as the predominant source of IFN gamma and link this induction with the SaeR/S two-component gene regulatory system. Relative to wild-type (BALB/c) mice, IFN gamma-deficient mice demonstrated increased bacterial clearance and reduced cellular cytotoxicity following intraperitoneal challenge with S. aureus. Interestingly, bacterial burden and cytotoxicity were similar in BALB/c and IFN gamma-deficient mice when infected with an isogenic saeR/S mutant strain. These findings suggest saeR/S-mediated neutrophil-derived IFN gamma diminishes innate antibacterial mechanisms against S. aureus. (C) 2013 Published by Elsevier Masson SAS on behalf of Institut Pasteur.
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