Journal
MICROBES AND INFECTION
Volume 15, Issue 1, Pages 1-10Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2012.10.011
Keywords
Host defense mechanism; Innate immunity; Toll-like receptor; TRIF
Categories
Funding
- National Institute of Allergy and Infectious Diseases [R56 AI095255-01, 1R01A1095255-01A1]
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Both anti-viral and anti-bacterial host defense mechanisms involve TRIF signaling. TRIF provides early clearance of pathogens and coordination of a local inflammatory ensemble through an interferon cascade, while it may trigger organ damage. The multipotentiality of TRIF-mediated immune machinery may direct the fate of our continuous battle with microbes. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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