Journal
MICROBES AND INFECTION
Volume 14, Issue 1, Pages 26-34Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2011.08.005
Keywords
Edwardsiella tarda; Human gastroenteritis; Virulence mechanisms; Bacterial secretion systems; T3SS and T6SS; Virulence regulation
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Funding
- Natural Science and Engineering Research Council (NSERC) [372373-2010]
- Trinity Western University [0488]
- Biomedical Research Council (BMRC) from the Agency for Science Technology and Research (A*STAR), Singapore [07/1/21/19/495]
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Human Edwardsiella tarda infections often manifest as gastroenteritis, but can become systemic and potentially lethal. E. tarda uses virulence factors that include type III and type VI secretion systems, quorum sensing, two-component systems, and exoenzymes to gain entry into and survive within the host. Better understanding of interactions between these factors will lead to the development of novel antimicrobials against E. tarda and other enterics. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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