Journal
MICROBES AND INFECTION
Volume 14, Issue 3, Pages 238-246Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2011.10.005
Keywords
Erythropoietin; Anemia; Innate immunity; Infection; Salmonella; Iron
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Funding
- Austrian research Funds [P-19664]
- Verein zur Forderung von Forschung und Weiterbildung in Infektiologie und Immunologie, Innsbruck
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Erythropoietin (EPO) is a multi-functional cytokine, which exerts erythropoietic effects but also carries anti-apoptotic and immune-modulatory activities upon binding to two distinct receptors which are expressed on erythroid, parenchymal and immune cells, respectively. Whereas EPO ameliorates hemolytic anemia in malaria or trypanosomiasis and improves the course of autoimmune diseases such as inflammatory bowel disease or autoimmune encephalomyelitis, it deleteriously inhibits macrophage functions in Salmonella infection in animal models. Thus, the specific modulation of extra-erythropoietic EPO activity forms an attractive therapeutic target in infection and inflammation. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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