Journal
MICROBES AND INFECTION
Volume 14, Issue 14, Pages 1284-1292Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2012.05.011
Keywords
ATP; NAD; P2X7; Danger signals; Tregs
Categories
Funding
- Inserm
- Association Francaise contre les Myopathies
- Deutsche Forschungsgemeinschaft
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Endogenous danger signals released during cell damage contribute to alert the immune system. Typically, their release results in the activation and maturation of innate immune cells, and the production of pro-inflammatory cytokines. In addition, extracellular NAD(+) stimulates immune responses by hindering regulatory T cells (Tregs), and could, therefore, represent the prototype of a new category of danger signals. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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