Journal
MICROBES AND INFECTION
Volume 14, Issue 3, Pages 273-278Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2011.10.007
Keywords
Bacteria-derived soluble factors; Bacteroides thetaiotaomicron; Intestine; Rotavirus; Glycosylation
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Rotaviruses attach to intestinal cells in a process that requires glycan recognition. Some bacteria from the gut microflora have been shown to modify cell-surface glycans. In this study, human intestinal cultured cells were incubated with bacteria-derived soluble factors and infected with rotavirus. Results show that only bacterial soluble factors that increase cell-surface galactose namely, those of Bacteroides thetaiotaomicron and Lactobacillus casei were able to efficiently block rotavirus infections. Increasing cell-surface galactose using galactosyltransferase resulted in a similar blockage of rotavirus infections. These results indicate that manipulation of cell-surface intestinal glycans by bacterial soluble factors can prevent rotavirus infection in a species-specific manner, and should now be considered a potential therapeutic approach against rotavirus infection. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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