Journal
MICROBES AND INFECTION
Volume 14, Issue 5, Pages 392-400Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2011.12.005
Keywords
Anthrax lethal toxin; Inflammasome; Caspase-1; Nlrp1; Nlrp1b; Bacillus anthracis
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Funding
- NIH, National Institute of Allergy and Infectious Diseases
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Anthrax lethal toxin (LT), a major virulence determinant of anthrax disease, induces vascular collapse in mice and rats. LT activates the Nlrp1 inflammasome in macrophages and dendritic cells, resulting in caspase-1 activation, IL-1 beta and IL-18 maturation and a rapid cell death (pyroptosis). This review presents the current understanding of LT-induced activation of Nlrp1 in cells and its consequences for toxin-mediated effects in rodent toxin and spore challenge models. Published by Elsevier Masson SAS on behalf of Institut Pasteur.
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