Journal
MICROBES AND INFECTION
Volume 14, Issue 5, Pages 419-426Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2011.11.015
Keywords
Viperin; Antiviral response; IFN-stimulated gene
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Viperin is an antiviral protein that is induced by different viruses, type I interferon, poly(I:C) and lipopolysaccharide, which is localized to the endoplasmic reticulum and lipid droplets. Recently, our knowledge on the mechanism by which viperin inhibits viral replication has strongly increased. Interestingly, it also became clear that viperin can be used by viruses to increase their infectivity. Here, our current knowledge on the induction of viperin and its effect on virus replication will be reviewed. (c) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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