Journal
MICROBES AND INFECTION
Volume 14, Issue 10, Pages 796-810Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2012.04.007
Keywords
Apicomplexa; Kinase inhibitor; Hidden Markov model; Protein classification; Drug target; Kinome
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Funding
- Japan Society for the Promotion of Science (JSPS) through the WPI-IFReC Research Program
- Kakenhi grant
- Kishimoto Foundation
- ETHZ-JST Japanese-Swiss Cooperative Program
- Spanish Ministry of Science and Innovation [BFU2009-09168]
- INSERM
- EPFL
- FP6 (SIGMAL and ANTIMAL projects, BioMalPar Network of Excellence)
- European Commission
- CNRS
- FP7 programmes MALSIG and PIROVAC
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Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we integrate genomic, biochemical, genetic and evolutionary information to provide an integrated and up-to-date analysis of twelve apicomplexan kinomes. All kinome sequences are available through the Kinomer database. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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