Journal
MICROBES AND INFECTION
Volume 14, Issue 3, Pages 247-261Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2011.10.006
Keywords
IL-15; Infectious diseases; Vaccines; Inflammation; Molecular adjuvants
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Funding
- Intramural NIH HHS [Z99 CA999999] Funding Source: Medline
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Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in many diverse cell types. It plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. This review provides an overview of the mechanisms by which IL-15 modulates the host response to infectious agents and its utility as a cytokine adjuvant in vaccines against infectious pathogens. Published by Elsevier Masson SAS on behalf of Institut Pasteur.
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