4.6 Article

Virulence and virulence factors in Entamoeba histolytica, the agent of human amoebiasis

Journal

MICROBES AND INFECTION
Volume 14, Issue 15, Pages 1428-1441

Publisher

ELSEVIER
DOI: 10.1016/j.micinf.2012.05.013

Keywords

Amoebiasis; Entamoeba; Parasite-host interactions; Stress response; Virulence

Funding

  1. French National Agency for Research (ANR)
  2. Pasteur-Weizmann Research Council
  3. ECOS-Nord program (France-Mexico)

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Human infections with Entamoeba histolytica sporadically become pathogenic, unknown triggers converting the parasite to its invasive phenotype. Parasite virulence results from complex host parasite interactions implicating multiple amoebic and host factors, eliciting host defence responses and parasite resistance to stress caused by the host reactions and changing environments during tissue invasion. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

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