Journal
MICROBES AND INFECTION
Volume 14, Issue 2, Pages 155-158Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2011.08.015
Keywords
Klebsiella pneumoniae; New Delhi metallo-beta-lactamase-1; Virulence; Animal study; Caenorhabditis elegans
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The aim of the study was to compare and evaluate virulence in five strains of Klebsiella pneumoniae, including an isolate carrying New Delhi metallo-beta-lactamase-1 (NDM-1). In vivo virulence was assessed using a murine sepsis model and using the nematode Caenorhabditis elegans killing model, and in vitro virulence by assessing various virulence factors. The NDM-1 carrying K. pneumoniae isolate was the most virulent in the murine sepsis model but there was no clear cut correlation to in vitro virulence factors or killing in C. elegans. It is concluded that K. pneumoniae carrying NDM-1 have an intrinsic virulence potential, which in coexistence with its multiresistance could promote and partly explain its epidemiological success. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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