Journal
MICROBES AND INFECTION
Volume 13, Issue 1, Pages 96-102Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2010.10.002
Keywords
Apicomplexa; Parasitic infection; Macrophage; Dendritic cell; Host pathogen interactions; Cell migration
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Funding
- Swedish Research Council
- Karolinska Institutet
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Recently, monocytic cells were suggested to systemically transport Toxoplasma tachyzoites during acute infection in mice. The mechanism underlying this shuttling function may partly be explained by dramatically enhanced host-cell motility upon parasite invasion. Here, we report that infection of human and murine macrophages in vitro resulted in augmented migration across a transwell membrane, linked to host-cell differentiation and to the parasite genotype. The hypemotility phenotype was absent in infected monocytes, NK, B or T-cells. In contrast to previous observations with dendritic cells, adoptive transfer of infected macrophages or lymphocytes did not exacerbate infection in mice compared to inoculation with free parasites. (C) 2010 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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