Journal
MICROBES AND INFECTION
Volume 13, Issue 14-15, Pages 1185-1190Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2011.08.006
Keywords
Enterococcus faecium; Enterococcal surface protein Esp; Endocarditis; Pathogenesis; Immunity
Categories
Funding
- European Union [LSHE-CT-2007-037410]
- ZonMW [0.6100.0008]
- NIH from the Division of Microbiology and Infectious Diseases, NIAID [R01 AI067861]
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The enterococcal surface protein Esp, specifically linked to nosocomial Enterococcus faecium, is involved in biofilm formation. To assess the role of Esp in endocarditis, a biofilm-associated infection, an Esp-expressing E. faecium strain (E1162) or its Esp-deficient mutant (E1162 Delta esp) were inoculated through a catheter into the left ventricle of rats. After 24 h, less E1162 Delta esp than E1162 were recovered from heart valve vegetations. In addition, anti-Esp antibodies were detected in Esp-positive E. faecium bacteremia and endocarditis patient sera. In conclusion, Esp contributes to colonization of E. faecium at the heart valves. Furthermore, systemic infection elicits an Esp-specific antibody response in humans. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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