Journal
MICROBES AND INFECTION
Volume 13, Issue 2, Pages 109-120Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2010.10.008
Keywords
NADPH oxidase; Dual oxidase; Oxidative stress
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Funding
- Chang Gung University [CMRPD160233, CMRPD 190421, CMRPG391681, CMRPD160313, CMRPD190441]
- National Science Council of Taiwan [NSC96-2320-B-182-015-MY3, NSC97-2320-B-182-013-MY3, NSC96-2320-B-182A-003-MY3, NSC99-2320-B-182A-005-MY3, NSC97-2320-B-182-015-MY3]
- Ministry of Education of Taiwan [EMRPD190211]
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Despite their prominent microbicidal roles, NADPH oxidases (NOXs) have been recently found to regulate a wide variety of physiological activities. Through generation of reactive oxygen species (ROS), NOXs actively participate in cellular activities, including NET formation, inflammasome activation and wound sensing. The microbicidal and cytoregulatory roles of NOXs are contrasted in this review. (c) 2010 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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