Journal
MICROBES AND INFECTION
Volume 13, Issue 4, Pages 312-321Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2011.01.002
Keywords
Japanese encephalitis; Neurotropic infection; Neuropathogenesis; Mosquito borne infections; Arboviral infections
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Funding
- Academy of Science Czech Republic (ASCR)
- Czech Republic and Council of Scientific and Industrial Research (CSIR), India [22/EU/Czech-CSIR/(18)/09-ISTAD)]
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Japanese encephalitis virus (JEV) is an arbovirus belonging to the family Flaviviridae. It is maintained in a zoonotic cycle involving pigs, ardeid birds and Culex species of mosquitoes. Humans are accidental/dead end hosts of JEV infection because they cannot sustain high viral titers. Factors affecting the clinical manifestations and pathogenesis of JEV infection are not well understood. Though, vaccines are currently available against JEV, it has to be further improved. Here we review the literature on the JEV life cycle, pathogenesis and host immune responses to JEV infection. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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