Journal
MICROBES AND INFECTION
Volume 13, Issue 1, Pages 58-64Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2010.10.001
Keywords
HIV-1; Old World monkey; TRIM5 alpha
Categories
Funding
- NIH [R24 RR016001, N01 AI040101]
- Japan Health Sciences Foundation
- Ministry of Health, Labor, and Welfare in Japan
- Kyoto University [A06]
- NATIONAL CENTER FOR RESEARCH RESOURCES [R24RR016001] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI040101] Funding Source: NIH RePORTER
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Human immunodeficiency virus type 1 (HIV-1) hardly replicates in Old World monkeys. Recently, a mutant HIV-1 clone, NL-DT5R, in which a small part of gag and the entire vif gene are replaced with SIVmac239-derived ones, was shown to be able to replicate in pigtail monkeys but not in rhesus monkeys (RM). In the present study, we found that a modified monkey-tropic HIV-1 (HIV-1mt), MN4-5S, acquired the ability to replicate efficiently in cynomolgus monkeys as compared with the NL-DT5R, while neither NL-DT5R nor MN4-5S replicated in RM cells. These results suggest that multiple determinants may be involved in the restriction of HIV-1 replication in macaques, depending on the species of macaques. The new HIV-1mt clone will be useful for studying molecular mechanisms by which anti-viral host factors regulate HIV-1 replication in macaques. (C) 2010 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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