Journal
MICROBES AND INFECTION
Volume 13, Issue 2, Pages 198-201Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2010.10.013
Keywords
C-type lectin receptors; Syk; CARD9; Dectin-1; Pulmonary disease; Inflammation
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Funding
- National Research Foundation
- Medical Research Council of South Africa
- Claude Leon Foundation
- University of Cape Town
- Wellcome Trust
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There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice. (C) 2010 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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