Journal
MICROBES AND INFECTION
Volume 12, Issue 1, Pages 3-10Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2009.09.005
Keywords
Immunology; Regulatory T cells; Brucella; Immune response; Mouse model
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Funding
- National Institutes of Health, National Institute of Allergy and Infectious Diseases
- Istituto Superiore di Sanita
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI001045] Funding Source: NIH RePORTER
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Brucellosis is one of the most common bacterial zoonoses worldwide. Infection is usually chronic and sometimes lifelong. Different mechanisms can be postulated as to the basis for the induction of the chronic status of brucellosis, but a comprehensive knowledge is still lacking. Here, we carried out a series of experiments in order to assess if the persistence of Brucella abortus could be ascribed to the effect of a down regulation of the immune response due to activity of regulatory T cells. We demonstrate that CD4 + CD25 + T regulatory cells are able to limit the effectiveness of CD4 + T cells and are able to favor the maintenance and the progression of B. abortus infection. (C) 2009 Elsevier Masson SAS. All rights reserved.
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