Journal
MICROBES AND INFECTION
Volume 12, Issue 14-15, Pages 1111-1119Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2010.08.008
Keywords
Interleukin-21; Immunity; Infection
Categories
Funding
- National Institutes of Health [R01 AI049360, R01 AI067933, U01 AI082966, T32 AI007051]
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Interleukin-21 (IL-21) is a cytokine that has broad effects on both innate and adaptive immune responses. The roles of IL-21 in determining immunity to infections are currently being defined, and notably, it has been shown that IL-21 is most critical for sustaining T cell responses during chronic viral infections. This article discusses our current understanding of the immunobiology of IL-21, as well as its known and potential roles in influencing immunity to infections. (C) 2010 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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