Journal
MICROBES AND INFECTION
Volume 12, Issue 3, Pages 173-181Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2009.12.001
Keywords
Epstein-Barr virus; Immune-evasion; Antigen presentation; Tumour virus; Herpesvirus; Immune response
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Funding
- Wellcome Trust
- Medical Research Council
- Medical Research Council [G9818340B] Funding Source: researchfish
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Persistent viruses have mechanisms for modulating the host immune responses that are essential for achieving a lifelong virus-host balance while minimizing the viral pathogenicity. Here we review some of the immune-modulating mechanisms evolved by the ubiquitous but potentially oncogenic Epstein-Barr virus, with particular emphasis on the molecular mechanisms of genes interfering with HLA class I antigen presentation. (C) 2009 Elsevier Masson SAS. All rights reserved.
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