Journal
MICROBES AND INFECTION
Volume 12, Issue 11, Pages 875-879Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2010.05.014
Keywords
Visceral leishmaniasis; Leishmania infantum; Sand fly; Transmission
Categories
Funding
- Wellcome Trust [064945, 078937, WT078223MA]
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We demonstrate that a proteophosphoglycan-rich gel secreted by Leishmania infantum inside the midgut of Lutzomyia longipalpis sand flies (promastigote secretory gel) is regurgitated along with an average dose of 500 L. infantum metacyclic promastigotes per infected bite. Using both low (10(3)) and high (10(5)) doses of parasites in the ears of BALB/c mice we show that the infections benefit from the presence of vector saliva and parasite gel in the skin. However, chronic infection of the spleen was only enhanced in high dose co-infections with gel. These results provide the framework for a more natural experimental model of visceral leishmaniasis. (C) 2010 Published by Elsevier Masson SAS on behalf of Institut Pasteur.
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