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The hygiene hypothesis: an evolutionary perspective

Journal

MICROBES AND INFECTION
Volume 12, Issue 6, Pages 421-427

Publisher

ELSEVIER
DOI: 10.1016/j.micinf.2010.02.002

Keywords

Natural selection; Population genetics; Host-pathogen interactions

Funding

  1. Istituto Superiore di Sanita'
  2. EMPRO
  3. AVIP EC [WP6]
  4. nGIN EC [WP7]
  5. Japan Health Science Foundation

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The hygiene hypothesis relies on the assumption that humans have adapted to a pathogen-rich environment that no longer exists in industrialized societies. Recent advances in molecular immunology and population genetics allow deeper insight into the evolution and co-evolution of host pathogen interactions and, therefore, into the foundations of the hygiene hypothesis. (C) 2010 Elsevier Masson SAS. All rights reserved.

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