Journal
MICROBES AND INFECTION
Volume 12, Issue 2, Pages 99-105Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2009.10.006
Keywords
Tuberculosis therapy; Therapeutic use of tuberculosis vaccines; Tuberculosis history
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Funding
- British Library (London, UK)
- St. Mary's Hospital library (London, UK)
- Spanish Ministry of Health [I+D+I FIS CM06/2044, 00123]
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The use of tuberculin for the therapy of tuberculosis was attempted more than 100 years ago and abandoned because of its adverse reactions. In this historical review we point out that some of the intensive efforts to avoid the reactions were based on the best scientific rationale available at that time. Balancing the dosage and intervals of tuberculin delivery with clinical and laboratory monitoring of patients achieved a limited success, with implications, toward current research in the field. The role of economical and social aspects at that time is also a lesson to be learned toward current approaches to tuberculosis control. (C) 2009 Elsevier Masson SAS. All rights reserved.
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