Journal
MICROBES AND INFECTION
Volume 12, Issue 10, Pages 784-789Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2010.05.015
Keywords
T. cruzi; Lysosomes; LAMP; Cell invasion
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- National Institutes of Health (NIH)
- World Health Organization (WHO-TDR)
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Trypanosoma cruzi host cell entry depends on lysosomes for the formation of the parasitophorous vacuole. Lysosome internal surface is covered by two major proteins, highly sialilated, Lysosome Associated Membrane Proteins 1 and 2. T. cruzi, on the other hand, needs to acquire sialic acid from its host cell through the activity of trans-sialidase, an event that contributes to host cell invasion and later for parasite vacuole escape. Using LAMP1/2 knock out cells we were able to show that these two proteins are important for T. cruzi infection of host cells, both in entrance and intracellular development, conceivably by being the major source of sialic acid for T. cruzi. (C) 2010 Elsevier Masson SAS. All rights reserved.
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