Journal
MICROBES AND INFECTION
Volume 11, Issue 4, Pages 452-459Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2009.02.004
Keywords
Granule exocytosis; Perforin; Granzymes; Cell death; Inflammation
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The granule exocytosis pathway of cytotoxic lymphocytes (Tc and NK cells) is critical for control of tumor development and viral infections. Granule-associated perforin and granzymes are key components in Tc cell-mediated function(s). On the basis of studies that showed granzymes A, B, C, K and M, to induce apoptosis it? vitro, all granzymes were thought to also induce cell death in vivo. This review summarizes our present understanding of the biological processes elicited by purified granzyme A and granzyme as well as the processes induced by the more physiologically relevant cytotoxic cells secreting these proteases. The combined evidence supports the concept that the granule secretion pathway is not mono-specific but rather poly-functional including induction of pro-inflammatory cytokines, besides their widely appreciated apoptotic properties. (C) 2009 Elsevier Masson SAS. All rights reserved.
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