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Chikungunya virus takes centre stage in virally induced arthritis: possible cellular and molecular mechanisms to pathogenesis

MICROBES AND INFECTION (2009)

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Journal

MICROBES AND INFECTION
Volume 11, Issue 14-15, Pages 1206-1218

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2009.10.001

Keywords

Virus; Arthritis; Immunology

Categories

Immunology Infectious Diseases Microbiology

Funding

  1. University of la Reunion
  2. French Ministry of Health [PRHC 2006-2009]
  3. French Overseas Ministry
  4. National Agency for Research
  5. Research Centre on Emerging Infectious Disease
  6. Regional council of la Reunion and Europe
  7. University of la Reunion
  8. French Ministry of Health [PRHC 2006-2009]
  9. French Overseas Ministry
  10. National Agency for Research
  11. Research Centre on Emerging Infectious Disease
  12. Regional council of la Reunion and Europe

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Chikungunya virus (CHIKV) causes an acute symptomatic illness with fever, skin rash (hypersensitivity vascultis), incapacitating arthralgia which can evolve to chronic arthritis in elderly patients. Clinical observations from cohort studies have been corroborated with data from experimental infection in several mouse and non-human primate models as discussed herein. (C) 2009 Elsevier Masson SAS. All rights reserved.

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