Journal
MICROBES AND INFECTION
Volume 11, Issue 3, Pages 321-327Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2008.12.011
Keywords
TLR; Negative regulation; Degradation; Deubiquitination
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Funding
- National Natural Science Foundation of China [30325018, 30530700]
- CAS project [KSCX1-YW-R-43]
- National Key Project 973 [2006CB504300, 2007CB512404]
- EU project [SP5B- CT-2006-044161]
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TLRs are primary sensors of invading pathogens, recognizing conserved microbial molecules and activating signaling pathways that are pivotal to innate and adaptive immune responses. However, a TLR signaling pathway must be tightly controlled because its excessive activation can contribute to the pathogenesis of many human diseases. This review provides a summary of the different mechanisms that are involved in the negative regulation of TLR signaling pathways. (C) 2009 Elsevier Masson SAS. All rights reserved.
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