Journal
MICROBES AND INFECTION
Volume 11, Issue 4, Pages 484-492Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2009.02.001
Keywords
Leishmania infantum; visceral leishmaniasis; microsatellite typing; polymorphism; population genetics, molecular epidemiology
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Funding
- Deutscher Akademischer Austauschdienst (DAAD)
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Multilocus microsatellite typing (MLMT) was used to investigate the genetic variation among 44 Israeli and Palestinian strains of L. infantum isolated from infected dogs and human cases to determine their population structure and to compare them with strains isolated from different European countries. Most of the Israeli and Palestinian strains had their own individual MLMT profiles; a few shared the same profile. A Bayesian model-based approach and phylogenetic reconstructions based on genetic distances inferred two main populations that were significantly different from the European strains: population A, containing 16 strains from places in the West Bank and I I strains from central Israel; and population B, containing 7 strains from northern Israel, 9 from central Israel, and one Palestinian strain from the Jenin District. Geographically distributed sub-populations were detected within population B. These results demonstrate similar disease dynamics in Israel and the Palestinian Authority. The re-emergence of VL in the case of population A is more likely owing to increased dog and human contact with sylvatic cycles of parasitic infection rather than to recent introduction from the older foci of northern Israel. The latter scenario could be true for population B found in few foci of Central Israel. (C) 2009 Elsevier Masson SAS. All rights reserved.
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