Journal
MICROBES AND INFECTION
Volume 10, Issue 8, Pages 922-927Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2008.05.001
Keywords
pathogenesis; innate immunity; intracellular
Categories
Funding
- Canadian Institutes of Health Research (CIHR)
- Howard Hughes Medical Institute (HHMI)
- Genome Canada
- Burroughs Wellcome Fund
- Canada Research Chair Award
- Michael Smith Foundation for Health Research (MSFHR)
- CIHR [MOP-68981]
- NSERC
- MSFHR
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We tested the hypothesis that host resistance to Campylobacter jejuni is Nramp I dependent. Following intraperitoneal (IP) inoculation of Nramp1+/+ and isogenic Nramp1-deficient (Nramp1-/-) mice C. jejuni primarily associated with mac1-positive cells in liver tissue. A significant reduction of C. jejuni was observed in Nramp1 +/+ mice 4 days post-infection (PI) (liver) and 8 days PI cecum-colon. In contrast, Nramp1 -/- mice showed no significant reduction of C. jejuni and instead had a chronic inflammatory response and significant histopathological lesions 30 days PI. Differential cytokine profiles were observed in C. jejuni infected Nramp1 +/+ and Nramp1 -/- primary dendritic cells. Taken together these data indicate that Nramp I is critical for host resistance to C. jejuni. (c) 2008 Elsevier Masson SAS. All rights reserved.
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