Journal
MICROBES AND INFECTION
Volume 10, Issue 9, Pages 1063-1066Publisher
ELSEVIER
DOI: 10.1016/j.micinf.2008.07.004
Keywords
Host; Pathogen; Heterogeneity; Single-cell
Categories
Funding
- Spanish Ministry of Science and Innovation [BIO2007-67457-C02-01, GEN2006-27776-C2-1-E]
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Tissue cultures have been successfully exploited to dissect Cellular and molecular mechanisms of microbial infections. Most of the methods used in this model conclude with data describing host and pathogen 'average' responses. Microscopy, however, reveals that such interplay is very diverse and that both partners are composed of phenotypically heterogeneous populations. Thus, upon co-incubation in the plate assay, neither all cultured host cells are infected nor all pathogen cells inflict alterations in host physiology. Despite its obvious impact in data interpretation, the basis of this heterogeneity remains in most cases unknown. Addressing this issue is encouraging since may contribute to uncover novel interactions in the host-pathogen scenario. (C) 2009 Elsevier Masson SAS. All rights reserved.
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