Journal
METHODS
Volume 68, Issue 1, Pages 265-272Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2014.03.031
Keywords
Drosophila; Heart; Development; Cardiomyopathy; Optical heartbeat analysis; Electrophysiology; Atomic force microscopy; Immunohistochemistry; KCNQ; Tinman
Funding
- NHLBI NIH HHS [R01 HL054732, P01 HL098053] Funding Source: Medline
- NIA NIH HHS [P01 AG033561] Funding Source: Medline
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In recent years the Drosophila heart has become an established model for many different aspects of human cardiac disease. This model has allowed identification of disease-causing mechanisms underlying congenital heart disease and cardiomyopathies and has permitted the study of underlying genetic, metabolic and age-related contributions to heart function. In this review we discuss methods currently employed in the analysis of the Drosophila heart structure and function, such as optical methods to infer heart function and performance, electrophysiological and mechanical approaches to characterize cardiac tissue properties, and conclude with histological techniques used in the study of heart development and adult structure. (c) 2014 Elsevier Inc. All rights reserved.
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