Journal
METHODS
Volume 56, Issue 4, Pages 514-518Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2012.03.016
Keywords
Electrochemiluminescence; Neurodegeneration; Parkinson's disease; Assay-development; alpha-synuclein
Funding
- Michael J. Fox Foundation for Parkinson's Research
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The need for improved diagnostic accuracy and markers of progression in neurodegenerative diseases motivates the identification of objective biomarkers as well as optimized assays for their quantification. Several potential marker candidates for Parkinson's disease (PD) in cerebrospinal fluid have been identified. These include alpha-synuclein, a major constituent of the intracellular aggregates. We give a general overview and details of our experience in converting established enzyme-linked immunoabsorbent assays (for alpha-synuclein and other proteins) onto an electrochemiluminescence-based platform as well as considerations on multiplexing different assays for PD. (c) 2012 Published by Elsevier Inc.
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