Journal
METHODS
Volume 48, Issue 2, Pages 161-177Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymeth.2009.03.012
Keywords
Molecular imaging; Peptide; Radiopharmaceutical; Positron emission tomography; PET; Single photon emission computed tomography; SPECT; Ga-68; Tc-99m; F-18; Cu-64; In-111
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Overexpressed neuropeptide receptors allow tumor visualization using e.g. radiolabeled peptidic receptor ligands and positron emission tomography (PET) or single photon emission computed tomography (SPECT). This review summarizes the development of radiolabeled probes for peptide receptor imaging since the emergence of the technology with a particular focus on peptide radiopharmaceuticals developed during the last 5 years, and highlights the different factors which are decisive during the process of tracer development and evaluation. (C) 2009 Elsevier Inc. All rights reserved.
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