Journal
METALLOMICS
Volume 10, Issue 11, Pages 1564-1569Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8mt00202a
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Funding
- National Key R&D Program of China [2017YFA0505400]
- National Science Foundation of China [21877103, 21573213]
- Major Program of Development Foundation of Hefei Center for Physical Science and Technology [2018ZYFX004]
- Suzhou Science and Technology Project [SYG201624]
- Jiangsu Natural Science Foundation [BK20151238]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
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Arsenic trioxide (ATO) is used in the clinic for the treatment of acute promyelocytic leukemia by targeting the protein PML. However, many zinc-finger proteins could also be reactive to arsenic in cells. Here we found that ATO preferentially binds to the ring-finger domain of PML in a protein mixture with zinc-finger domains. These results provide the molecular basis of the target selection of ATO in cells.
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