Journal
METALLOMICS
Volume 6, Issue 5, Pages 1023-1033Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4mt00061g
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Funding
- DFG [SCHW903/4-1]
- Austrian Science Fund (FWF) [I550-N17]
- Graduate School of Chemistry (WWU Munster, Germany)
- Austrian Science Fund (FWF) [I 550] Funding Source: researchfish
- Austrian Science Fund (FWF) [I550] Funding Source: Austrian Science Fund (FWF)
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Arsenic-containing hydrocarbons are one group of fat-soluble organic arsenic compounds (arsenolipids) found in marine fish and other seafood. A risk assessment of arsenolipids is urgently needed, but has not been possible because of the total lack of toxicological data. In this study the cellular toxicity of three arsenic-containing hydrocarbons was investigated in cultured human bladder (UROtsa) and liver (HepG2) cells. Cytotoxicity of the arsenic-containing hydrocarbons was comparable to that of arsenite, which was applied as the toxic reference arsenical. A large cellular accumulation of arsenic, as measured by ICP-MS/MS, was observed after incubation of both cell lines with the arsenolipids. Moreover, the toxic mode of action shown by the three arsenic-containing hydrocarbons seemed to differ from that observed for arsenite. Evidence suggests that the high cytotoxic potential of the lipophilic arsenicals results from a decrease in the cellular energy level. This first in vitro based risk assessment cannot exclude a risk to human health related to the presence of arsenolipids in seafood, and indicates the urgent need for further toxicity studies in experimental animals to fully assess this possible risk.
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