Journal
METALLOMICS
Volume 4, Issue 4, Pages 379-388Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2mt20010d
Keywords
-
Categories
Funding
- SNF [FN 200020_126366, PDFMP2_127457]
- NCCR nanosciences from SNF
- Professur fur Molecular Bionics
- Swiss National Science Foundation (SNF) [PDFMP2_127457] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Among natural metalloenzymes, the facial two-histidines one-carboxylate binding motif (FTM) is a widely represented first coordination sphere motif present in the active site of a variety of metalloenzymes. A PDB search revealed a total of 1685 structures bearing such FTMs bound to a metal. Sixty statistically representative FTMs were selected and used as template for the identification of structurally characterized proteins bearing these three amino acids in a propitious environment for binding to a transition metal. This geometrical superposition search, carried out using the STAMPS software, returned 2320 hits. While most consisted of either apo-FTMs or bore strong sequence homology to known FTMs, seven such structures lying within a cavity were identified as novel and viable scaffolds for the creation of artificial metalloenzymes bearing an FTM.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available