Journal
METALLOMICS
Volume 4, Issue 1, Pages 33-36Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1mt00161b
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The interaction of the potent anti-diabetic agent bis(maltolato)-oxidovanadium(IV) (BMOV) with some proteins of blood serum was studied by EPR spectroscopy, pH-potentiometry and DFT calculations. The formation of cis-VO(ma)(2)(hTf), cis-VO(ma)(2)(HSA) and cis-VO(ma)(2)(IgG), their role in the biotransformation in vivo and the mechanism of transport of BMOV in blood are discussed.
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